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单颗粒电感耦合等离子体飞行时间质谱（Single Particle-Inductively Coupled Plasma Time-ofFlight Mass Spectrometry,SP-ICP-TOF-MS）和单细胞电感耦合等离子体飞行时间质谱（Single CellInductively Coupled Plasma Time-of-Flight Mass Spectrometry,SC-ICP-TOF-MS）技术是纳米材料分析、生物医药分析的前沿技术，通过等离子体离子源与飞行时间质谱仪的结合，实现了单颗粒、单细胞全质量范围多元素/同位素的同步快速采集，突破了传统四极杆SP-ICP-MS和SC-ICP-MS的技术瓶颈。本文阐述了该技术的核心原理与发展历程，梳理其软硬件关键改进，对比分析其与主流表征技术的性能及适用场景，重点综述其在环境、材料、生物医学、食品及法医溯源等领域的典型应用，同时剖析技术现存局限性，并展望了算法优化、前处理标准化、跨技术联用等未来发展方向。该技术凭借高通量、高灵敏度、多元素同步检测的优势，成为纳米及亚微米尺度物质分析的前沿工具，为环境监测、精准医学等领域发展提供重要技术支撑。
Abstract：Single particle inductively coupled plasma time-of-flight mass spectrometry(SP-ICP-TOF-MS) and single cell inductively coupled plasma time-of-flight mass spectrometry(SC-ICP-TOF-MS) are cutting-edge technologies in nanomaterials analysis and biomedical analysis. By combining a plasma ion source with a time-offlight mass spectrometer,the techniques enabled simultaneous and rapid acquisition of multi-element/isotope signals across the entire mass range for single particles and single cells,breaking through the technical bottlenecks of traditional quadrupole-based SP-ICP-MS and SC-ICP-MS. This review described the principles and development history of the technologies,summarized key improvements in hardware and software,compared their performance and applicable scenarios with mainstream particle characterization techniques,and highlighted typical applications in environmental science,materials science,biomedicine,food analysis,and forensic tracing. It also analyzed current limitations and discussed future development directions such as algorithm optimization,standardization of sample pretreatment,and cross-technique hyphenation. With the advantages of high throughput,high sensitivity,and multi-element simultaneous detection,SP-ICP-TOF-MS and SC-ICP-TOF-MS became advanced tools for analyzing nanomaterials and submicron-scale materials,providing important technical support for environmental monitoring,precision medicine,and related fields.
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基本信息:
DOI：10.20236/j.CJIAC.2026.06.002
中图分类号:O657.63
引用信息:
[1]黄智聪,刘洪涛,栾天罡.单颗粒/单细胞电感耦合等离子体飞行时间质谱技术研究进展及其应用[J].中国无机分析化学,2026,16(06):927-942.DOI:10.20236/j.CJIAC.2026.06.002.
基金信息:
国家重大科研仪器研制项目(22127810); 中山大学科研仪器功能开发创新项目(2025YQ4-1);中山大学分析测试中心实验技术开发及仪器改造专项~~
2026-04-16
2026-04-16
2026-04-16