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在分析科学日益追求从宏观统计向微观个体解析转变的背景下,单颗粒电感耦合等离子体质谱(SP-ICP-MS)技术应运而生,并迅速发展为表征纳米颗粒乃至生物颗粒的强大平台。本综述系统阐述了SP-ICP-MS的技术原理、仪器方法学关键参数优化及数据处理策略;重点梳理了其在纳米材料相关工业、环境科学及生物医学领域的广泛应用,涵盖从材料合成表征、环境行为追踪到单细胞异质性解析等多个领域;展望了该技术朝向多元素检测、联用技术集成及数据分析智能化发展的前沿趋势,旨在为相关领域的深入研究提供技术参考与发展视角。
Abstract:With the trend in analytical science increasingly moving from macroscopic statistics to microscopic individual analysis,single particle inductively coupled plasma mass spectrometry(SP-ICP-MS) technology has emerged and rapidly developed into a powerful platform for characterizing nanoparticles and even biological particles. This review systematically elucidates the technical principles of SP-ICP-MS,the optimization of key instrumental parameters,and data processing strategies. It focuses on summarizing its wide applications in fields related to nanomaterials,environmental science,and biomedicine,covering aspects from material synthesis characterization and environmental behavior tracking to single-cell heterogeneity analysis. Furthermore,it prospects the cutting-edge trends of this technology towards multi-element detection,integration of hyphenated techniques,and intelligent data analysis,aiming to provide technical reference and developmental perspectives for in-depth research in related fields.
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基本信息:
DOI:10.20236/j.CJIAC.2026.03.002
中图分类号:O657.63
引用信息:
[1]刘美君,魏星,杨婷,等.单颗粒电感耦合等离子体质谱(SP-ICP-MS)分析技术:原理、应用与前沿进展[J].中国无机分析化学,2026,16(03):351-362.DOI:10.20236/j.CJIAC.2026.03.002.
基金信息:
国家自然科学基金资助项目(22374014); 中央高校基本科研业务费优秀博士项目(N2405006)~~
2025-12-12
2025-12-12
2025-12-12